Environmental Sciences: Ramon Lavado-Parra

Ramon Lavado-Parra

Marine Pollution Biomonitoring: Evaluation of toxic effects of bioaccumulative chemicals in complex mixtures and media, such as contaminated waters and the effects of toxic chemicals on aquatic life at various levels of organization, including molecular, cellular, organ, physiology, reproduction, whole organism growth, and population effects.
Studies of endocrine disruption associated to environmental pollutants of concern.
Drug Metabolizing Enzymes: Evaluation of the role of cytochrome P450 and flavin-containing monooxygenases in the activation and detoxification of organophosphate and pyrethroid insecticides. Of particular interest is the impact of environmental changes on the expression and catalytic activities of these enzymes
Development of Biomarkers: Development of new biomarkers of effects and exposure in wildlife, related to steroidogenesis and metabolism of pesticides and other compounds.

Lavado, R., Rimoldi, J. M. and Schlenk, D. Mechanisms of fenthion activation in rainbow trout (Oncorhynchus mykiss) acclimated to hypersaline environments. Toxicology and Applied Pharmacology 235 (2009), 143-152.
Lavado, R., Loyo-Rosales, J. E., Floyd, E., Kolodziej, E. P., Snyder, S. A., Sedlak, D.L. and Schlenk, D. Site-specific profiles of estrogenic activity in agricultural areas of California’s inland waters. Environmental Science and Technology 43 (2009), 9110-9116.
Bulloch, D., Lavado, R. and Schlenk D. Bioassay guided Fractionation (Toxicity Identification and Evaluation) for the determination of estrogenic agents in environmental samples. In: Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations. American Chemical Society. ACS Press. Chapter 26, pp 519-537 (2010). Chapter DOI: 10.1021/bk-2010-1048.ch026.
Lavado, R. and Schlenk, D. Microsomal biotransformation of chlorpyrifos, parathion and fenthion in rainbow trout (Oncorhynchus mykiss) and coho salmon (Oncorhynchus kisutch): Mechanistic insights into interspecific differences in toxicity. Aquatic Toxicology 101 (2011), 57-63.
Lavado, R.,Maryoung, L. A. and Schlenk D. Hypersaline acclimation increases phorate toxicity in coho salmon (Oncorhynchus kisutch). Environmental Science and Technology (2011). In Press (dx.doi.org/10.1021/es200451j).