Office: 316 Science Laboratories I
Phone: (951) 827-2018
Email: daniel.schlenk@ucr.edu
His research focuses on understanding the biochemical factors that influence susceptibility to environmental and natural chemicals. Four specific projects involve the use of bioassays in the identification of environmental estrogens and other endocrine disrupting compounds in reclaimed water, wastewater and sediments; mechanistic investigations of the effects of salinity on pesticide and selenium toxicity in fish; the role of biotransformation as a mechanism of tolerance to natural and man-made toxic agents; and applied aquaculture research.
Dr. Schlenk’s honors include his selection as the North American Co-editor in Chief of Aquatic Toxicology, a University of Mississippi School of Pharmacy Research Award, two fellowships from the National Institute of Environmental Health Sciences, and appointments as a Ray Lankester Fellow at the Marine Biological Association of the United Kingdom and as a visiting scholar at the Chinese University of Hong Kong and the Instituto Del Mare in Venice.
Roy, L. A., J. L. Armstrong , K. Sakamoto, S. Steinert , E. Perkins, D. P. Lomax , L. L. Johnson and D.Schlenk (2003) The relationships of biochemical endpoints to histopathology, and population metrics in feral flatfish species collected near the municipal outfall of Orange County,CA. Environmental Toxicology and Chemistry 22:1309-1317.
Furnes, B., J., Feng, S..Sommer, and D. Schlenk (2003) Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. Drug Metabolism and Disposition 31:187-193.
Cashman, J. R., K. Camp, S. S. Fakharzadeh, P. V. Fennessey, R. N. Hines, O. A. Mamer, S. C. Mitchell, G. Preti, D. Schlenk, R. L. Smith, S. S. Tjoa, D. E. Williams and S. Yannicelli (2003) Biochemical and Clinical Aspects of the Human Flavin-Containing Monooxygenase Form 3 (FMO3) Related to Trimethylaminuria. Current Drug Metabolism 4: 151-170.
Schlenk, D. (2003) Use of Biochemical Endpoints to determine relationships between contaminants and impaired fish health in a freshwater stream. Human and Ecological Risk Assessment 9:59-66.
Huggett, D.B., C.M. Foran, B.Brooks, J. Weston, B.P. Peterson, E.M. Marsh, D.Schlenk (2003) Comparison of In vitro and in vivo bioassays for estrogenicity in fractionated effluent from Municipal Wastewater Effluents. Toxicological Sciences 72:77-83.
Kuhajek, J. M. and D. Schlenk (2003) Effects of the brominated phenol, lanosol, on cytochrome P-450 and glutathione transferase activities in Haliotis rufescens and Katharina tunicata. Comparative Biochemistry and Physiology 134C:473-479.
Lattard, V., J. Zhang, Q., Tran, B. Furnes, D. Schlenk, , J. R. Cashman (2003) Two novel polymorphisms of the FMO3 gene in Caucasians and African American populations: Comparative genetic and functional studies. Drug Metabolism and Dispostion 31:854-860.
Roy, L. A., S. Steinert, S.M. Bay, D. Greenstein, Y. Sapozhnikova, O. Bawardi, I. Leifer and D. Schlenk (2003) Biochemical effects of PAH exposure in hornyhead turbot (Pleuronichthysverticalis) exposed to a gradient of PAH contaminated sediments collected from a natural petroleum seep in CA, USA. Aquatic Toxicology 65:159-169.
Schlenk, D., N. Zubcov, E. Zubcov (2003) Effects of salinity on the uptake, biotransformation and toxicity of dietary seleno-l-methionine to rainbow trout. Toxicological Sciences 75:309-313.
Schlenk, D., C. Yeung, A. Rettie (2004) Unique Stereoselective Sulfoxidation of Thioethers Indicates Novel Flavin-Containing Monooxygenase in Liver of Rainbow Trout. Marine Environmental Research 58:499-503.
Sapozhnikova, E., O. Bawardi, L.Roy, D. Schlenk, D (2004) Pesticides and PCBs in sediments and fish from the Salton Sea, California, USA. Chemosphere 55:797-809.
K. K. Schrader, C. M. Foran, B. D. Holmes, D. K. Schlenk, N. P. D, Nanayakkara, B. T. Schaneberg (2004) Toxicological Evaluation of Two Anthraquinone-based Cyanobactericides. North American Journal of Aquaculture 66:119-124.
B. Furnes and D.Schlenk (2004) Evaluation of Xenobiotic N- and S-oxidation by Variant Flavin-containing Monooxygenase 1 (FMO1) Enzymes. Toxicological Sciences 78:196-203.
D. Schlenk, C. Yeung, A. Rettie (2004) Unique Stereoselective Sulfoxidation of Thioethers Indicates Novel Flavin-Containing Monooxygenase in Liver of Rainbow Trout. Marine Environmental Research 58:499-503.
L. Xie, Y. Sapozhnikova, O. Bawardi, and D. Schlenk (2005) Evaluation of wetland and tertiary wastewater treatments for estrogenicity using in vivo and in vitro assays. Archives of Environmental Contamination and Toxicology 48: 82-87.
D. Schlenk, Y. Sapozhnikova, G. Cliff. (2005) Incidence of organochlorine pesticides in muscle and liver tissues of South African great white sharks Carcharodon carcharias. Marine Pollution Bulletin 50: 208-211.
B. Furnes and D.Schlenk (2005) Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the FMO and P450 system. Drug Metabolism and Disposition 33: 214-218.
Y. Sapozhnikova, E. Zubcova, L. Ungureanu, L.Roy, D. Schlenk (2005) Evaluation of pesticides and metals in fish of the Dniester river, Moldova Chemosphere 60:196-205.
D. Vidal, S.Bay, D.Schlenk (2005) Effects of selenium accumulation on larval rainbow trout (Oncorhynchus mykiss). Archives of Environmental Contamination and Toxicology 49:71-75.
W. Liu, J. Gan, D. Schlenk, W. A. Jury (2005) Enantioselectivity in Environmental Safety of Current Chiral Insecticides. Proceedings of the National Academy of Sciences 102 : 701-706.
C. Seruto, Y. Sapozhnikova, D.Schlenk (2005) Evaluation of the Relationships Between Biochemical Endpoints of PAH Exposure and Physiological Endpoints of Reproduction in Male California Halibut (Paralichthys californicus) Exposed to Sediments from a Natural Oil Seep. Marine Environmental Research 69:454-465.
Y. Sapozhnikova, E. Zubcova, L. Ungureanu, S. Hungerford, D. Schlenk (2005) Evaluation of organic and inorganic compounds in sediments of the Dniester River, Moldova . Archives of Environmental Contamination and Toxicology 49:439-448.
D. Schlenk, Y. Sapozhnikova, M.A. Irwin, L. Xie, W. Hwang, S. Reddy, B.J. Brownawell, J. Armstrong, M. Kelly, D. E. Montagne, E. P. Kolodziej, D. Sedlak, S.Snyder (2005) In vivo Bioassay Guided Fractionation of Marine Sediment Extracts from the Southern California Bight for Estrogenic Activity. Environmental Toxicology and Chemistry 24:2820-2826.
L. Xie, K. Thrippleton, M.A. Irwin, G. S. Siemering, A. Mekebri, D. Crane, K. Berry and D. Schlenk (2005). Evaluation of Estrogenic Activities of Aquatic Herbicides and Surfactants Using A Rainbow Trout Vitellogenin Assay. Toxicological Sciences 87: 391-398.
P.B. Bedient, R.D. Horsak, D.Schlenk, R.M. Hovinga, J.D. Pierson (2005) Environmental impact of fipronil to the Louisiana crawfish industry. Environmental Forensics 6: 289-299.
Department of Environmental Sciences
University of California, Riverside
Riverside, CA 92521
Fax: (951) 827-3993